Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd
Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd
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Home>Products>Prohormones Steroids>Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment

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  • Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment
  • Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment
  • Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment
  • Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment

Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment

  • Hongkong Saichuang
  • Pharmaceutical raw material

  • China
  • ISO9001
  • 10grams
  • Negotiated
  • foil bag
  • Within 3-7days after received payment
  • T/T, Western Union, MoneyGram
  • 5000kg per month
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Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd

Hongkong Pengfei Pharmaceutical  Technology  Co.,LtdChina

  • Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd2020-07-10 09:46:19
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Product Details

Product Name: Trilostane Routes of administration: oral ATC code: H02CA01
Legal status: US Metabolism: Hepatic IUPAC name: (4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Synonyms: 4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile Number: 13647-35-3 PubChem: 656583
DrugBank: DB01108 ChemSpider: 570949 UNII: L0FPV48Q5R
KEGG: D01180 ChEBI: CHEBI ChEMBL: CHEMBL1200907
Formula: C20H27NO3 Molar mass: 329.433 g/mol Appearance: White powder
Assay: 99%

Product Description

Pharmaceutical raw material of Trilostane white powder for Breast Cancer Treatment no 13647-35-3

  • Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
  • Trilostane
  • Synonym: Vetoryl
  • :13647-35-3
  • Alias:99%
  • Einecs No:237-133-0
  • Grade : Pharmaceutical Grade
  • Storage: Shading, confined preservation
  • Appearance:: White crystalline powder

Trilostane Info

Trilostane blocks an enzyme active in the production of several steroide including cortisol. Inhibiting this enzyme inhibits producing cortisol. In Cushings syndrome, the adrenal gland overproduces steroide. Although steroide are crucial for various functions with the body, too much can cause problems. Trilostane decreases the amount of steroide made by the adrenal gland.
Test Items Specification Test Results
Appearance white oralmost white,crystalline powder Conform
Solubility Freely soluble in water,practically insoluble or very slightly
soluble in alcohol and in methylene chloride.
Conform
Identification A The UV absorption spectrum of the sample shows
an absorption maximum at 276nm.The specific
absorbance at the Maximum is55 to 64.
Conform
B Infraed absorption spectrophotometry. Conform
C Chromatogram obtained with test solution (b) is
similar in position color & size to the principal spot in the
chromatogram obtained with the reference solution.
Conform
D An orange-red color develop in methylene chloride layer. Conform
E It geves reaction (a) of sulphates. Conform
Appearance of solution Solution S is clear and not more intensely coloured than
reference solution in BY6.
Conform
Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color
of the indicator to red.
Conform
Related substances Impurity J ≤0.20% Conform
Any other impurity ≤0.30% Conform
Total impurity ≤1.0% Conform
Boron ≤50ppm Conform
Sulphated ash ≤0.10% 0.06%
Loss on drying ≤0.5% 0.30%
Assay(on dried basis) 98.0~101.0% 99.5%


Trilostane Applications:

Trilostane is utilized in the treating Cushings syndrome. It can be normally used in short-term treatment until permanent care is possible.
Trilostane blocks an enzyme mixed up in production of several steroids including cortisol. Inhibiting this enzyme inhibits making cortisol. In Cushings syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions with the body, excessive can cause problems. Trilostane cuts down on the amount of steroids made by the adrenal gland.

Trilostane produces suppression from the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.

Our advantages:


1. Top quality and factory price,a discount would be given when you make a large order.
2. Rich experienced in delivering,package will be reshipped if sent failed.
3. Enough stock ensure the prompt delivery time.
4. Good after-sales service,any of your question would be solved for the first as soon as possible.
5. Adhering to the principle of customer first conviction,we will provide the best and the most sincere services as possible as we can.

Contact info:

Smith Sun


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