Pharmaceutical Raw Material Trilostane White Powder For Breast Cancer Treatment

Trilostane Info

Trilostane blocks an enzyme active in the production of several steroide including cortisol. Inhibiting this enzyme inhibits producing cortisol. In Cushings syndrome, the adrenal gland overproduces steroide. Although steroide are crucial for various functions with the body, too much can cause problems. Trilostane decreases the amount of steroide made by the adrenal gland.

Test Items		Specification	Test Results
Appearance		white oralmost white,crystalline powder	Conform
Solubility		Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.	Conform
Identification	A	The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.	Conform
	B	Infraed absorption spectrophotometry.	Conform
	C	Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.	Conform
	D	An orange-red color develop in methylene chloride layer.	Conform
	E	It geves reaction (a) of sulphates.	Conform
Appearance of solution		Solution S is clear and not more intensely coloured than reference solution in BY6.	Conform
Optical rotation		negative 0.10° to +0.10°determined on solution S.	+0.01°
Acidity or alkalinity		NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red.	Conform
Related substances		Impurity J ≤0.20%	Conform
		Any other impurity ≤0.30%	Conform
		Total impurity ≤1.0%	Conform
Boron		≤50ppm	Conform
Sulphated ash		≤0.10%	0.06%
Loss on drying		≤0.5%	0.30%
Assay(on dried basis)		98.0~101.0%	99.5%

Trilostane Applications:

Trilostane is utilized in the treating Cushings syndrome. It can be normally used in short-term treatment until permanent care is possible.
Trilostane blocks an enzyme mixed up in production of several steroids including cortisol. Inhibiting this enzyme inhibits making cortisol. In Cushings syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions with the body, excessive can cause problems. Trilostane cuts down on the amount of steroids made by the adrenal gland.

Trilostane produces suppression from the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.

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1. Top quality and factory price,a discount would be given when you make a large order.
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5. Adhering to the principle of customer first conviction,we will provide the best and the most sincere services as possible as we can.

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