Indomethacin powder Pharmaceutical Raw Materials Non steroid anti-inflammatory

BP standard Indomethacin powder Non steroid anti-inflammatory analgesic Indometacin

53-86-1

Indometacin Basic information:

Name: Indometacin
: 53-86-1
MF: C19H16ClNO4
MW: 357.79
Standard: BP
Purity: Pharmaceutical grade 99%
Appearance: white crystalline powder
chemical properties: White or slightly yellow crystalline powder. Melting point is 158-162℃, soluble in acetone, slightly soluble in ethanol, chloroform, ether, almost insoluble in water.
Uses:
1.The product is anti-inflammatory, and antipyretic effect is obvious, mainly is used for salicylates to tolerance or the effect is not significant rheumatism and arthritis, ankylosing light spondylitis, osteoarthritis.
2.Non steroid anti-inflammatory analgesic
Packing: 25KG / Fiber drum

Indometacin Description:

It can be used for acute and chronic rheumatoid arthritis, gouty arthritis and cancer pain (western medicine cancer pain medicine). It can also be used for bursitis, tenosynovitis and joint capsule Inflammation, etc .; anti-platelet aggregation, it can prevent thrombosis, but less effective than acetylsalicylic acid; Behcet syndrome treatment, antipyretic effect is good; for Batter syndrome, the effect is particularly significant; for biliary colic, ureteral stones Angina caused by effective; migraine also have a certain effect, can also be used for menstrual pain.

Indications:

Detoxification, blood circulation, swelling and pain relief, sore throat for heat toxic blood stasis, toothache, Bitong pain, pain in the ribs
Jaundice, nameless swelling and pain of the disease.
Can also be used for neonatal patent ductus arteriosus.

Usage:

Oral: At the beginning of each serving 25mg, 1 2 to 3 times, immediately after meals or after meals (to reduce gastrointestinal adverse reactions). Treatment of rheumatoid arthritis, etc., if no adverse reactions, can be gradually increased to 125 ~ 150mg daily.
Now also use capsules or suppository formulations, gastrointestinal adverse reactions to reduce the incidence of suppository has the characteristics of maintaining a longer duration of the drug, the general even 10 days for a course of treatment.

Precautions:

1. Common adverse reactions are gastrointestinal reactions (nausea, vomiting, abdominal pain, diarrhea, ulcers, and sometimes gastric bleeding and perforation caused). After taking this capsule, can reduce gastrointestinal reactions.
2. Central nervous system symptoms (headache, dizziness, etc.) the incidence is not low (20% to 50%), if the headache continued unabated, should be discontinued.
3. Can cause damage to liver function (jaundice, elevated transaminases).
4. Inhibit the hematopoietic system (such as neutropenia, ocional aplastic anemia).

Drug effect:
(1) This product and acetaminophen long-term use, can increase the side effects of the kidney. Combined with other non-steroidal anti-inflammatory drugs, the incidence of peptic ulcer increased.
(2) with aspirin or other salicylates at the same time, can not increase the efficacy, and significantly increased gastrointestinal side effects, and increase bleeding tendency. (3) alcohol or with corticosteroids, adrenocorticotropic hormone used in conjunction, can increase gastrointestinal ulcer or bleeding tendency.
(4) combined with heparin, oral anticoagulant, thrombolytic drugs, there is a potential risk of increased bleeding tendency.
(5) combined with triamterene can cause gastric dysfunction.
(6) with colchicine, sulfinpyrazole can increase the risk of gastrointestinal ulcers and bleeding.