Pharma Grade Powder D-Biotin / Vitamin H For Health No.58-85-5

Pharma Grade Powder D-Biotin / Vitamin H For Health No.58-85-5

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Description

D-Biotin, also called Vitamin H, is a colorless, water-soluble member of the group of B-vitamins. Formerly it was known as vitamin H or coenzyme R. It has many benefits for the hair, skin, and nails.
It is composed of a ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.
Subclinical deficiency of Biotin can cause mild symptoms, such as hair thinning or skin rash typically on the face. Thus, This product is recommended for general food fortification and dietary supplement applications.

Generally, D-Biotin can be used for baby food and dietetics, for solid and liquid pharmaceutical preparations, for cosmetic preparations, and for use in the fermentation industry.

No.58-85-5
Chemical Name:D-Biotin
SynonymsBIOTIN;BIOS H;biosii;Bios II;Ritatin;Meribin;BIOTINUM;FACTOR S;D-BIOTIN;Bios-IIb
CBNumber:CB3271542
Molecular Formula:C10H16N2O3S
Melting point:231-233 °C(lit.)
alpha 89 º (c=1, 0.1N NaOH)
refractive index 90.5 ° (C=2, 0.1mol/L NaOH)
storage temp. 2-8°C
solubility H2O: 0.2 mg/mL Solubility increases with addition of 1 N NaOH.
form powder
PH4.5 (0.1g/l, H2O)
Water Solubility Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.
Sensitive Light Sensitive
Hazard Codes:Xn
Risk Statements:20/21/22-36/37/38
Safety Statements24/25-36-26
WGK Germany:1
HS Code:29362930

Stability:Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids, formaldehyde, chloramine-T, nitrous acid.
Quality Standard: USP30 calculated in dry drugs, biotin content between 97.5% -100.5%.
Features: Biotin is a white crystalline powder; very slightly soluble in water and ethanol, insoluble in common organic solvents. In acid and neutral solutions moderate-intensity stable for a few days, less stable in alkaline solution.

Usage and purpose: to help the metabolism of amino acids and carbohydrates promote normal functioning of sweat glands, spiritual organizations, bone marrow, male gonads, skin and hair growth and skin inflammation prevent gray hair and hair loss, baldness treatment helps maintain the normal function of the skin, reduce eczema, ease muscle pain.

Physicochemical property

Biotin is widely distributed in animals and plants, and the natural presence of biotin is mainly in the form of binding with other molecules. The biochemical structure of biotin includes a shuttle chain containing five carbon atoms and two five-membered heterocycles. In vivo the shuttle of the side chain binds with lysine s residue of enzyme protein, playing a role of coenzyme. Biotin may have 8 different isomers, of which only D-biotin has biological activity. Under normal circumstances, biotin is quite stable, only in the strong acid, alkali, formaldehyde and UV treatment will be destroyed. Biotin is the carrier of carboxyl in the carboxylation reaction required large ATP. The carboxyl group is temporarily bound to a nitrogen atom on the bicyclic ring system of biotin, such as in the reaction of pyruvate carboxylase catalyzing the pyruvate carboxylation of oxaloacetate.

Applications

As a feed additive, it is mainly used for poultry and sow feed. Usually the premixed mass fraction is 1%-2%.
It is nutritional supplement. According to China GB2760-90 regulations, it could be used as a food industry as a processing aid. It has physiological functions to prevent skin diseases and promote lipid metabolism and so on.
It is carboxylase coenzyme, involved in many carboxylation reactions, and is an important coenzyme in the metabolism of sugar, protein and fat.
It is used as food fortifier. It is used for infant food with amount of 0.1~0.4mg/kg, in the drinking liquid 0.02~0.08mg/kg.
It could be used for labeling proteins, antigens, antibodies, nucleic acids (DNA, RNA) and so on.

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