Anti Acnes Powder Accutane / Isotretinoin / 13-Cis Retinoic Acid : 4759-48-2

Anti Acnes Powder Accutane / Isotretinoin / 13-Cis Retinoic Acid : 4759-48-2

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Isotretinoin Description:

Isotretinoin (etymology and pronunciation), also known as 13-cis retinoic acid and first marketed, is a medication primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related tovitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

Name: Isotretinoin
Alias: 13-cis Vitamin A acid
: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Categories:Antibiotics, Organicacids, APIs, Pharmaceuticals, Retinoids
Character: yellow or orange crystalline powder
Solubility: practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96%);
Stability: air, light, heat-sensitive, solution stability worse
Loss on drying: ≤0.5%
Content: 99.8%MIN
Heavy Metal: ≤20ppm
Cell culture Test: Pass
Uses: For the treatment of severe acne embolism
Storage conditions: room temperature, damp and dark airtight and dry.

Function:

1.works as an isomer of Vitamin A, which reduces the amount of oil released by the oil glands in the skin; this will make it difficult for acne to form and reduce it significantly. Nearly all patients achieve clearing of acne during a course, with 90% reportingexcellent results with higher dosages.
2.Bodybuilders who use anabolic steroids have utilized isotretinoin to counteract the negative effects of steroids on their skin; especially, the acne related side effects.

Isotretinoin Applications:

Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments Acne treatment usually begins with topical retinoids (e.g., tretinoin, adapalene), in combination with topical antibiotics (e.g.,erythromycin) or antiseptics (e.g., benzoyl peroxide-containing preparations), followed by oral antibiotics In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications.

In es of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.

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