Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd
Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd
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Home>Products>Pharmaceutical Raw Materials>Fulvestrant white powder Pharmaceutical Raw Materials cancer treatment no 129453

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  • Fulvestrant white powder Pharmaceutical Raw Materials cancer treatment no 129453
  • Fulvestrant white powder Pharmaceutical Raw Materials cancer treatment no 129453

Fulvestrant white powder Pharmaceutical Raw Materials cancer treatment no 129453

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  • Pharmaceutical raw materials

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Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd

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  • Hongkong Pengfei Pharmaceutical  Technology  Co.,Ltd2020-07-10 09:46:19
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Product Details

Product Name: fulvestrant Trade names: Faslodex Pregnancy category: D
Routes of administration: Intramuscular injection ATC code: L02BA03 Legal status: In general
Protein binding: 99% IUPAC name: (7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol Number: 129453-61-8
PubChem: 104741 DrugBank: DB00947 ChemSpider: 94553
UNII: 22X328QOC4 KEGG: D01161 ChEBI: CHEBI
ChEMBL: CHEMBL1358 Formula: C32H47F5O3S Molar mass: 606.772 g/mol
Assay: 99% Appearance: White powder

Product Description

Fulvestrant white powder Pharmaceutical Raw Materials cancer treatment no 129453-61-8

1. Basic Info

Synonyms: FASLODEX
Chemical Name:(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
Density:1.201 g/cm3
Melting Point:104-106°C
Boiling Point:674.8 °C at 760 mmHg
Usage:To treat estrogen receptor positive metastatic breast cancer in postmenopausal women, with disease progression following antiestrogen therapy.


2. Description

Fulvestrant also called Faslodex or AstraZeneca,is is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It works by blocking the actions of estrogen in the body. Fulvestrant is a complete estrogen receptor antagonist with no agonist effects, which in addition, accelerates the proteasomal degradation of the estrogen receptor. The drug has poor oral bioavailability, and is administered monthly via intramuscular injection.Certain types of breast cancer use estrogen to grow and multiply in the body.do not use fulvestrant if you are allergic to any ingredient in fulvestrant ,and Contact your doctor or health care provider right away if any of these apply to you.

3. Application

Fulvestrant is used to treat some hormone-related breast cancer and postmenopausal women whose breast cancer has progressed after treatment with other anti-estrogen medication.It is an estrogen receptor antagonist and works by blocking estrogen from tumors that need estrogen to grow.

Fulvestrant is also being studied in the treatment of other types of cancer,it is used to treat hormone receptor positive breast cancer in women who have experienced menopause and whose breast cancer has worsened after they were treated with antiestrogen medications such as tamoxifen.This can slow or stop the growth of some breast tumors that need estrogen to grow.

Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone; These breast cancers are called hormone sensitive or hormone receptor positive; Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells; Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cell has.

Fulvestrant Acetate Faslode; AstraZeneca; is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy; It is an estrogen receptor antagonist with no agonist effects; which works by down-regulating the estrogen receptor

Fulvestrant Acetate is a selective estrogen receptor down-regulator Fulvestrant is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy; The dosing schedule for fulvestrant remains under investigation in an attempt to optimize its effectiveness

COA

Test Item Specification Results
Appearance white crystalline powder A white crystalline powder
Identification The retention time of the major peak in the chromatogram of the assay preparation is same as that of the standard preparation obtained in the assay Conform
Any Individual impurity Not more than 0.10% 0.18%
Total impurities Not more than 1.0% 0.44%
Ratio of isomers Fulvestran A 50.0%-60.0% 51.70%
Fulvestran B 40.0%-50.0% 47.86%
purity 99.0% 99.56%



4. Precaution

Before starting fulvestrant treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc).
Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
Fulvestrant may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.
Do not breast feed while taking this medication.

5. Dosage

The recommended Letrozole dosage in adults is 2.5 mg tablet taken by mouth once per day.

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