Nicarbazin Yellow Powder Pharmaceutical Raw Materials For Anti Coccidiosis Drugs

Nicarbazin Yellow Powder Pharmaceutical Raw Materials For Anti Coccidiosis Drugs , No 330-95-0

Product name: Nicarbazin
Synonyms: 1,3-bis(4-nitrophenyl)urea-4,6-dimethylpyrimidin-2-ol (1: 1); NICARBAZIN; NICARBAZINE; NICARBAZINUM; N,N-BIS(4-NITROPHENYL)UREA COMPOUND WITH 4,6-DIMETHYL-2-PYRIMIDINONE; carbanilide,4,4 -dinitro-,compd.with4,6-dimethyl-2-pyrimidinol(1: 1); mk75; n,n -bis(4-nitrophenyl)ureacompd.with4,6-dimethyl-2-pyrimidinol(1: 1)
No.: 330-95-0
Molecular formula: C19H18N6O6
Molecular weight: 426.38
EINECS No.: 206-359-1
Chemical properties: light yellow crystalline powder. Melting point265-275°C (decompound).
Assay: 98%
Packing: 25kg/Cardboard drum
Place of Origin: Zhejiang,China (Mainland)
: 330-95-0
Molecular Formula: C19H18N6O6
Molecular Weight: 426.3828
EINECS: 206-359-1
Boiling point: 414.8°C at 760 mmHg
Flash point: 204.7°C
Vapour Pressur: 4.32E-07mmHg at 25°C
Hazard Symbols: Xi:Irritant;
Risk Codes: R36/37/38:
Safety Description:S26:; S36

Chemical Properties

Light yellow crystalline powder, no foul. Mp 265-275 ℃ (decomposition). Non-hygroscopic, insoluble in water, ethanol, chloroform and ether, slightly soluble in dimethylformamide. Grinding and water will slowly break down, decompose quickly in dilute acid.

use

The product of chicken cecal coccidiosis and stack-shaped Eimeria, Eimeria tenella, Eimeria poison, Bordetella Eimeria have a good preventive effect. With high efficiency, low toxicity, stable performance, the advantages of small resistance. It can be used with coccidia ester combination better. Note: ① laying hens disabled; ② discontinued four days before slaughter; when the temperature is above 45 ℃ ③ disabled.

use

Anti coccidiosis drugs for the treatment of coccidiosis

Production method

1 is composed of 4,4-nitro stilbene urea (DNC) and acetyl acetone and urea cyclization compound.

(1) DNC synthesis. Methyl amine and nitrobenzene by paranitroaniline reflux in dimethyl formamide (DMF) in the condensation, yield 85% -90%; p-nitroaniline and also by the reaction of phosgene in toluene and too, yield 96.5%; or nitrobenzene hydrochloride, in dibutyl phthalate with urea condensation heating is made.

50g nitroaniline was added 180mL of concentrated hydrochloric acid, warmed to dissolve with stirring, and reacted at reflux micro 1.5h. After cooling, the precipitated bright yellow leaf-shaped p-nitroanilide hydrochloride crystals, m.p. 173-174 ℃, 95% yield.

The hydrochloride 10.2g (0.0584mol) and 1.5g (0.025mol) of urea was added 60mL dibutyl phthalate, the reaction was stirred at 180 ℃ in 6h. Cooling to 20 ℃ filtered, washed with ethanol, water, washed with a small amount of toluene and dried to give a yellow green powder DNC, m.p. 310-314 ℃ (decomposition), yield 65%.

(2) Synthesis of nicarbazin. The 8.1g (0.027mol) DNC, 2.5g (0.042mol) urea, 4mL acetylacetone and a small amount of concentrated hydrochloric acid were added 35mL of anhydrous ethanol, the reaction mixture was stirred at reflux for 10-15h, cooled to room temperature and crystallized, isolated by centrifugation, ethanol washed, and dried to give a yellow composite powder, yield 80%

2 consists of 4,4 urea nitro stilbene (DNC) and 2-hydroxy-4,6-dimethyl-pyrimidine (HDP) at a molar ratio of 1: 1 complex. HDP prepared from acetylacetone and urea condensation reaction
competitive Advantage:

1. Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.

Payment method: T/T, Western union, Moneygram
2. Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .
4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. We have stock, so we can delivery quickly at the very day when receive the payment.
6. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.
7. A discount would be given when you make a large order.

Supply Ability: Mass Stock

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