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146-48-5 Male Enhancement Steroids Yohimbine Hydrochloride Raw Material Powder
- Hongkong
Mens enhancers
- Hubei China
- ISO9001
- 100grams
- Negotiated
- Foil bag
- Within 3-7days after received payment
- T/T, Western Union, MoneyGram
- 5000kg per month
Hongkong Pengfei Pharmaceutical Technology Co.,LtdChina
-
Hongkong Pengfei Pharmaceutical Technology Co.,Ltd2020-07-10 09:46:19
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Product Details
| Product Name: | Yohimbine | no: | 146-48-5 | PubChem: | 8969 |
| IUPHAR/BPS: | 102 | DrugBank: | DB01392 | ChemSpider: | 8622 |
| UNII: | 2Y49VWD90Q | ChEBI: | CHEBI | ChEMBL: | CHEMBL15245 |
| Formula: | C21H26N2O3 | Molar mass: | 354.44 g/mol (base) 390.90 g/mol (hydrochloride) | Appearance: | White crystal powder |
| Assay: | >97% |
Product Description
Mens hormone Yohimbine hydrochloride raw material powder for sport nutrition no 146-48-5
Description:
| Yohimbine | Product ID: E-0271 | ||
| Number | 146-48-5 | ||
| Alias Name | Quebrachine, Johimbin | ||
| Purity (HPLC) | >97% | ||
| Molecular Formula | C21H26N2O3 | ||
| Molecular Weight (g/mol) | 354.44274 | ||
| Chemical Name | 2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2,3:3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester | ||
| General Source | Corynante Yohimbe | ||
| Product Appearance | white powder | ||
| Package Size | 10mg/20mg/500mg/1g/10g standard packing or according to customers requirement | ||
Quality Inspection
• Been tested by at least three liquid-phase detection systems. Annually retest will be made to ensure
product quality
• Being confirmed by mass spectrometry (MS) and nuclear magnetic resonance (NMR)
• COA and HPLC will be shipped togther with products
Yohimbine is an derived from the bark of the tree in Central Africa. It is a veterinary drug used to reverse sedation in dogs and deer. Yohimbine has been studied as a potential treatment for but there is insufficient evidence to rate its effectiveness. Extracts from yohimbe have been marketed as dietary supplements for improving sexual function.
Uses
Yohimbine is a drug used in veterinary medicine to reverse the effects of xylazine in dogs and deer.
Yohimbe extracts, which contain yohimbine, have been used in traditional medicine and marketed as dietary supplements.
Toxicity
Depending on dosage, yohimbine can either increase or decrease systemic blood pressure (throughvasoconstriction or vasodilation, respectively). Because yohimbine has highest affinity for the α2receptor, small doses can increase blood pressure by causing a relatively selective α2 blockade. Yohimbine also, however, interacts with α1 receptors, albeit with lower affinity; therefore, at higher doses an α1blockade can occur and overwhelm the effects of the α2 blockade, leading to a potentially dangerous drop in blood pressure. Higher doses of oral yohimbine may create numerous side effects, such as rapid heart rate, overstimulation, anomalous blood pressure, cold sweating, and insomnia.
Extracts and chemistry
Yohimbe (Pausinystalia johimbe) is a tree that grows in western and central Africa; yohimbine was originally extracted from the bark of yohimbe in 1896 by Adolph Spiegel. In 1943 the correct constitution of yohimbine was proposed by Witkop. Fifteen years later, Van Tamelen used a 23-step synthesis to become the first person to achieve the synthesis of yohimbine.
Pharmacology
Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A,5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, andD3 receptors. It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A. Yohimbine interacts with serotonin and dopamine receptors in high concentrations.
Research
Sexual dysfunction
Yohimbine has been studied as a potential treatment for but there is insufficient evidence to rate its effectiveness. It is illegal in the United States to market an over the counter product containing yohimbine as a treatment for without getting FDA approval to do so.
Yohimbine blocks the pre- and post-synaptic α2 receptors. Blockade of post-synaptic α2 receptors causes only minor corpus cavernosum smooth musclerelaxation, due to the fact that the majority of adrenoceptors in the corpus cavernosum are of the α1 type. Blockade of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system — thus in the corpus cavernosum — such as nitric oxide and norepinephrine. Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions, however, nitric oxide attenuates norepinephrine vasoconstriction.
Packaging
• Stored in a brown and screw reagent bottle
• It will be packaged with specially designed bubble box to make sure will not be damaged during transport
• Ice bag will be added to package for products,to ensure the product will not be effected by temperature
Storage
• The product is placed in a sealed box with desiccant or saved in a freezer at 4 ℃ after dried by the
desiccant dryer,
• Detailed information and storage conditions are showed in every product label, as well as a unique Article No. and corresponding marking number, to ensure the traceability of each product in production, packaging,
storage, transportation and marketing.
Application Area:
FOR RESEARCH USE ONLY
1. Quantitative determination
2. Identification
3. Active experiment - cell experiments, animal experiments
Features and advantages of the products
- Strictly quality control and thoroughly testing of products (1HNMR 13CNMR MS HPLC)
- Part of our reference materials were certified by China General Administration of Quality Supervision- National Research Center for Certified Reference Standards
- With the help of perfect store and supply system, all products will be supplied on time
- Tauto reference materials have been accepted by many companies, distributors and research institutes in United States, Germany, Switzerland, United Kingdom, and Singapore etc
Contact info:
Skype:Shun Sun1987
Email:
Whatsapp:+8618872220694
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